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METHODS: We recruited 150 children (2-6 years of age) with physician-diagnosed asthma from inner-city Baltimore, Maryland. Indoor air was monitored over a 72-hr period in the children's bedrooms at baseline and 3 and 6 months.

Data from the National Health and Nutrition Examination Survey (NHANES) demonstrate the impact of elevated [NO.sub.2] levels on morbidity in children. A recent study found that higher outdoor NO.sub.2 levels were associated with increased prevalence of upper respiratory symptoms in African American children and that this relationship was attenuated among children from inner-city communities (Beelen et al. 2006). Furthermore, Nouri et al. (2002) demonstrated that [NO.sub.2] levels were associated with decreased lung function in adults, and our group has observed similar effects of [NO.sub.2] in children (Breysse et al. 2005). However, NO.sub.2 has also been implicated in acute asthma exacerbations (Stenvers and Bogers 1995; Stenvers et al. 2002; Tsai et al. 2004), and it is currently unknown whether [NO.sub.2] exposure increases acute asthma symptoms. Therefore, we hypothesized that higher concentrations of NO.sub.2 would be associated with increased asthma symptoms in preschool children.

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